Association of serum lutein and zeaxanthin with quantitative measures of retinal vascular parameters

PLoS One. 2018 Sep 27;13(9):e0203868. doi: 10.1371/journal.pone.0203868. eCollection 2018.

Abstract

To evaluate the association between serum carotenoids and quantitative measures of retinal vasculature in elderly Singapore Chinese subjects. The following details were collected in 128 healthy subjects: sociodemographics, lifestyle information, medical and drug history, and anthropometric measurements. Serum concentrations of carotenoids were estimated in fasting venous blood using high performance liquid chromatography. Retinal vascular parameters were quantitatively measured from retinal photographs using a computer-assisted program (Singapore I Vessel Assessment). The mean age of the population was 54.1 years (range 40 to 81 years). In multiple linear regression analysis, per SD decrease in retinal arteriolar caliber [β = 0.045 (0.003 to 0.086), p = 0.036], per SD increase in retinal venular caliber [β = -0.045 (-0.086 to -0.003), p = 0.036] and per SD increase in arteriolar branching angle [β = -0.039 (-0.072 to -0.006), p = 0.021] were associated with decreased serum lutein. Per SD increase in retinal venular tortuosity [β = -0.0075 (-0.0145 to -0.0004), p = 0.039] and per SD increase in arteriolar branching angle (β = -0.0073 [-0.0142 to -0.0059], p = 0.041) were associated with decreased serum zeaxanthin. None of the other carotenoids demonstrated meaningful relationship with quantitative measures of retinal vasculature. Lower levels of lutein and zeaxanthin demonstrated significant relationship with adverse quantitative measures of retinal vasculature in elderly healthy subjects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Asian Continental Ancestry Group / genetics
  • Blood Pressure
  • Carotenoids / blood
  • China
  • Cross-Sectional Studies
  • Eye Diseases / metabolism
  • Female
  • Humans
  • Lutein / analysis*
  • Lutein / blood
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Regression Analysis
  • Retina / diagnostic imaging*
  • Retina / metabolism
  • Retinal Vessels / chemistry
  • Retinal Vessels / metabolism
  • Singapore / epidemiology
  • Venules
  • Zeaxanthins / analysis*
  • Zeaxanthins / blood

Substances

  • Zeaxanthins
  • Carotenoids
  • Lutein

Grant support

This study was supported by Small Innovative grant I for the year 2012, awarded to NK by Alexandra Health Private Limited. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.