Rebound hypertension after discontinuation of transdermal clonidine therapy

Am J Med. 1987 Jan;82(1):17-9. doi: 10.1016/0002-9343(87)90371-8.


Three (and possibly all four) elderly hypertensive patients who were followed sequentially after discontinuation of transdermal clonidine monotherapy manifested a rapid rise in blood pressure to levels above control (pre- and post-therapy) readings. No signs of an "overshoot" in plasma norepinephrine levels or symptoms of beta-adrenergic overactivity were seen. Such rebound hypertension suggests hypersensitivity to alpha-adrenergic receptor stimulation and could pose a heretofore unreported potential hazard to elderly or otherwise compromised patients who discontinue transdermal clonidine therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Cutaneous
  • Aged
  • Blood Pressure
  • Clonidine / administration & dosage
  • Clonidine / adverse effects*
  • Humans
  • Hypertension / chemically induced*
  • Male
  • Norepinephrine / blood
  • Receptors, Adrenergic, alpha / drug effects
  • Risk
  • Substance Withdrawal Syndrome / etiology*


  • Receptors, Adrenergic, alpha
  • Clonidine
  • Norepinephrine