Matrix Metalloproteinase-9 (MMP-9) as a Cancer Biomarker and MMP-9 Biosensors: Recent Advances

Sensors (Basel). 2018 Sep 27;18(10):3249. doi: 10.3390/s18103249.


As one of the most widely investigated matrix metalloproteinases (MMPs), MMP-9 is a significant protease which plays vital roles in many biological processes. MMP-9 can cleave many extracellular matrix (ECM) proteins to regulate ECM remodeling. It can also cleave many plasma surface proteins to release them from the cell surface. MMP-9 has been widely found to relate to the pathology of cancers, including but not limited to invasion, metastasis and angiogenesis. Some recent research evaluated the value of MMP-9 as biomarkers to various specific cancers. Besides, recent research of MMP-9 biosensors discovered various novel MMP-9 biosensors to detect this enzyme. In this review, some recent advances in exploring MMP-9 as a biomarker in different cancers are summarized, and recent discoveries of novel MMP-9 biosensors are also presented.

Keywords: biomarker; biosensor; cancer detection; cancers; matrix metalloproteinase-9; matrix metalloproteinases.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomarkers, Tumor / analysis*
  • Biosensing Techniques / methods*
  • Humans
  • Matrix Metalloproteinase 9 / analysis*
  • Neoplasms / blood supply
  • Neoplasms / enzymology*
  • Neoplasms / pathology


  • Biomarkers, Tumor
  • Matrix Metalloproteinase 9