Etiology of infective complications was investigated in 71 injured persons, suffering severe burns. There was established, that the main causing agents in patients, suffering burn disease, are S. aureus(in 35.9% of observations), A. baumannii (in 25%), P. aeruginosa (in 12.82%), P. mirabilis (in 5.12%). Resistance of conditionally pathogenic microorganisms towards cephalosporins, аminoglycosides, іmipenem, meropenem, doxycycline was determined. Effective bactericidal activity of antiseptic solutions of decasan, miramistinum, chlorhexidine was proved. High antimicrobial properties of dressing materials, which contain decametoxine, chlorhexidine, furagin, silver ions against Staphylococcus were noted. Clinical efficacy of application of materials, impregnated by antimicrobial composition decametoxine with carboxymethylstarch, oxyethylcellulose and polyvynilacetate, for prophylaxis and treatment of infective purulent—inflammatory complications in patients, suffering burns, was proved.