Chronic demyelinating peripheral neuropathy associated with multifocal central nervous system demyelination

Brain. 1987 Feb;110 ( Pt 1):53-76. doi: 10.1093/brain/110.1.53.


A series of 6 cases is described in which a chronic demyelinating neuropathy was associated with a relapsing multifocal CNS disorder, the clinical features of which resembled multiple sclerosis. Multifocal CNS lesions were demonstrated by CT and MR imaging and the presence of CNS demyelination was indicated by prolonged central conduction times. These cases are discussed in relation to the occurrence of combined peripheral and central demyelination in chronic relapsing experimental allergic encephalomyelitis and neuritis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials
  • Adult
  • Central Nervous System Diseases / complications*
  • Central Nervous System Diseases / diagnosis
  • Demyelinating Diseases / diagnosis*
  • Demyelinating Diseases / physiopathology
  • Evoked Potentials, Somatosensory
  • Evoked Potentials, Visual
  • Female
  • Humans
  • Magnetic Resonance Spectroscopy
  • Male
  • Middle Aged
  • Neural Conduction
  • Peripheral Nervous System Diseases / complications*
  • Peripheral Nervous System Diseases / diagnosis