Butyric acid: Applications and recent advances in its bioproduction

Ling Jiang; Hongxin Fu; Hopen K Yang; Wei Xu; Jufang Wang; Shang-Tian Yang

doi:10.1016/j.biotechadv.2018.09.005

Butyric acid: Applications and recent advances in its bioproduction

Biotechnol Adv. 2018 Dec;36(8):2101-2117. doi: 10.1016/j.biotechadv.2018.09.005. Epub 2018 Sep 26.

Authors

Ling Jiang¹, Hongxin Fu², Hopen K Yang³, Wei Xu⁴, Jufang Wang⁵, Shang-Tian Yang⁶

Affiliations

¹ School of Biology & Biological Engineering, South China University of Technology, Guangzhou 510006, China; College of Food Science and Light Industry, Nanjing Tech University, No. 5 Xinmofan Road, Nanjing 210009, China.
² School of Biology & Biological Engineering, South China University of Technology, Guangzhou 510006, China.
³ Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA.
⁴ Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA; School of Chemical and Biological Engineering, Yancheng Institute of Technology, Yancheng 224051, China.
⁵ School of Biology & Biological Engineering, South China University of Technology, Guangzhou 510006, China; Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA. Electronic address: jufwang@scut.edu.cn.
⁶ Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA. Electronic address: yang.15@osu.edu.

PMID: 30266343
DOI: 10.1016/j.biotechadv.2018.09.005

Abstract

Butyric acid is an important C4 organic acid with broad applications. It is currently produced by chemosynthesis from petroleum-based feedstocks. However, the fermentative production of butyric acid from renewable feedstocks has received growing attention because of consumer demand for green products and natural ingredients in foods, pharmaceuticals, animal feed supplements, and cosmetics. In this review, strategies for improving microbial butyric acid production, including strain engineering and novel fermentation process development are discussed and compared regarding product yield, titer, purity and productivity. Future perspectives on strain and process improvements for butyric acid production are also discussed.

Keywords: Butyric acid; Clostridia; Fermentation; Metabolic engineering; Product recovery; Renewable feedstock.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Bioreactors / microbiology*
Butyric Acid / metabolism*
Clostridium* / enzymology
Clostridium* / genetics
Clostridium* / metabolism
Fermentation
Metabolic Engineering*
Metabolic Networks and Pathways

Substances

Butyric Acid