Retrovirus antigens recognized by cytolytic T lymphocytes activate tumor rejection in vivo

Cell. 1987 Jan 30;48(2):231-40. doi: 10.1016/0092-8674(87)90426-0.

Abstract

We have initiated the molecular definition of the antigens recognized by Gross MuLV-specific cytolytic T lymphocytes on the surface of Gross MuLV-induced tumor cells. A panel of target cells was obtained by the double transfection and expression of a retrovirus gene and a foreign H-2 gene in recipient mouse fibroblasts. Our results show that class I H-2 transplantation antigens have a directive influence in determining the antigenicity of proteins encoded by the gag and env MuLV genes. Genes not linked to H-2 influence the intensity and the specificity of the cytolytic T lymphocyte response to Gross MuLV-induced tumors. Finally, MuLV-induced antigens expressed by transfected fibroblasts induce tumor immunity and lead to accelerated tumor rejection in vivo.

MeSH terms

  • AKR murine leukemia virus / genetics
  • AKR murine leukemia virus / immunology*
  • Animals
  • Antigens, Viral / immunology*
  • Gene Products, gag
  • Genes, Viral
  • H-2 Antigens / genetics
  • H-2 Antigens / immunology
  • Leukemia Virus, Murine / immunology*
  • Leukemia, Experimental / immunology*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Inbred Strains
  • Retroviridae Proteins / immunology
  • T-Lymphocytes, Cytotoxic / immunology*
  • Transfection
  • Viral Envelope Proteins / immunology

Substances

  • Antigens, Viral
  • Gene Products, gag
  • H-2 Antigens
  • Retroviridae Proteins
  • Viral Envelope Proteins