Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency

Affiliations

• ¹ Dr. von Hauner Children's Hospital, Department of Pediatrics, University Hospital LMU München, Munich, Germany.
• ² German Cancer Consortium (DKTK), Heidelberg, Germany; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.
• ³ German Cancer Consortium (DKTK), Heidelberg, Germany; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Biological Sciences, Goethe University Frankfurt, Frankfurt, Germany.
• ⁴ Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.
• ⁵ Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
• ⁶ Division of Pediatric Gastroenterology and Nutrition, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat-Gan, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
• ⁷ Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Pediatric Immunology Unit, The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.
• ⁸ BIOSS Centre for Biological Signaling Studies, University of Freiburg, Freiburg, Germany; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Institute of Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Germany; CIBSS Centre for Integrated Biological Signaling Studies, University of Freiburg, Freiburg, Germany.
• ⁹ Princess Maxima Center and the Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, The Netherlands.
• ¹⁰ Department of Paediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
• ¹¹ SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.
• ¹² SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
• ¹³ Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts; Division of Gastroenterology, Brigham and Women's Hospital, Boston, Massachusetts.
• ¹⁴ Dr. von Hauner Children's Hospital, Department of Pediatrics, University Hospital LMU München, Munich, Germany; Department of Pediatrics, Division of Gastroenterology, Nephrology and Metabolic Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.
• ¹⁵ Dr. von Hauner Children's Hospital, Department of Pediatrics, University Hospital LMU München, Munich, Germany. Electronic address: daniel.kotlarz@med.uni-muenchen.de.