Distinctive epileptogenic networks for parietal operculum seizures

Epilepsy Behav. 2019 Feb;91:59-67. doi: 10.1016/j.yebeh.2018.08.031. Epub 2018 Sep 27.

Abstract

Objective: The present study investigated the electroclinical features and epileptogenic networks of parietal operculum seizures (POS) by using stereoelectroencephalography (SEEG) intracerebral recordings.

Methods: Comprehensive presurgical evaluation data of seven patients with drug-resistant epilepsy with POS were analyzed retrospectively. Stereoelectroencephalography-recorded seizures were processed visually and quantitatively by using epileptogenicity mapping (EM), which has been proposed to ergonomically quantify the epileptogenicity of brain structures with a neuroimaging approach.

Results: Six patients reported initial somatosensory or viscerosensitive symptoms. Ictal clinical signs comprised frequently nocturnal hypermotor seizures and contralateral focal motor seizures, including tonic, tonic-clonic, or dystonic seizures of the face and limbs. Interictal and ictal scalp EEG provided information regarding lateralization in the majority of patients, but the discharges were widely distributed over perisylvian or "rolandic-like" regions and the vertex. Furthermore, two subgroups of epileptogenic network organization were identified within POS by SEEG, visually and quantitatively, using an EM approach: group 1 (mesial frontal/cingulate networks) was observed in three patients who mainly exhibited hypermotor seizures; group 2 (perisylvian networks) was observed in four patients who mainly exhibited contralateral focal motor seizures.

Conclusion: This study indicated that POS could be characterized by initial specific somatosensory sensations, followed by either frequently nocturnal hypermotor seizures or contralateral focal motor seizures. The distinctive seizure semiology depended on the organization of two primary epileptogenic networks. This article is part of the Special Issue "Individualized Epilepsy Management: Medicines, Surgery and Beyond.

Keywords: Brain networks; Epileptogenicity map; Parietal epilepsy; SEEG.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Child
  • Drug Resistant Epilepsy / diagnostic imaging
  • Drug Resistant Epilepsy / physiopathology*
  • Drug Resistant Epilepsy / surgery
  • Electroencephalography / methods*
  • Female
  • Humans
  • Male
  • Nerve Net / diagnostic imaging
  • Nerve Net / physiopathology*
  • Parietal Lobe / diagnostic imaging
  • Parietal Lobe / physiopathology*
  • Parietal Lobe / surgery
  • Retrospective Studies
  • Seizures / diagnostic imaging
  • Seizures / physiopathology*
  • Seizures / surgery
  • Stereotaxic Techniques
  • Temporal Lobe / diagnostic imaging
  • Temporal Lobe / physiopathology*