Effect of high-fat, standard, and functional food meals on esophageal and gastric pH in patients with gastroesophageal reflux disease and healthy subjects

J Dig Dis. 2018 Nov;19(11):664-673. doi: 10.1111/1751-2980.12676. Epub 2018 Nov 15.


Objectives: To investigate the effects of different test meals on esophageal and intragastric pH in patients with gastroesophageal reflux disease (GERD) and healthy subjects and to demonstrate the relationship between esophageal acid exposure (EAE) and gastric pH.

Methods: We enrolled patients with reflux esophagitis (RE; n = 15), nonerosive reflux disease (NERD; n = 12) and healthy subjects (n = 10). Four pH electrodes were used to monitor the pH of the distal esophagus, upper border of the lower esophageal sphincter, gastric fundus, and gastric body for 26 hours. Isocaloric and isovolumetric high-fat, standard, and functional meals were supplied randomly to the participants. The EAE and gastric acidity of each meal in fasting and postprandial states were compared.

Results: High-fat meals significantly increased postprandial EAE in patients with RE and NERD. EAE was higher after a high-fat meal than after a standard or functional food meals at the fourth hour postprandially in patients with RE (P < 0.05). Patients with NERD reported fewer symptoms after a functional food meal than after high-fat and standard meals (0 [interquartile range {IQR} 0-1] vs 1 [IQR 0-2] vs 3 [IQR 1-4], P = 0.014). Compared with high-fat and standard meals, functional food meal significantly decreased gastric acidity in patients with RE. EAE was significantly related to gastric acidity in patients with RE.

Conclusions: High-fat meals increased EAE in patients with RE and NERD. Functional food could serve as adjuvant therapy in GERD patients. EAE was related to gastric acidity in RE patients.

Keywords: diet; functional food; gastric acid; gastroesophageal reflux; high-fat diet.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Case-Control Studies
  • Diet, High-Fat*
  • Esophageal pH Monitoring / methods
  • Esophagogastric Junction / physiopathology
  • Female
  • Functional Food*
  • Gastric Acidity Determination
  • Gastroesophageal Reflux / diet therapy*
  • Gastroesophageal Reflux / metabolism*
  • Humans
  • Hydrogen-Ion Concentration
  • Male
  • Manometry / methods
  • Middle Aged
  • Young Adult