Memory, Novelty and Prior Knowledge

Trends Neurosci. 2018 Oct;41(10):654-659. doi: 10.1016/j.tins.2018.08.006. Epub 2018 Sep 25.


Over the 40 years that TINS has been in existence, there has been substantial progress in understanding the types, organisation, and neural mechanisms of memory. The selectivity of memory maintenance and retention remains a puzzle, and we here summarise two contributions of our own research to this enigma: the striking impact of the novelty and surprise often of other events happening around the time that a new memory is encoded and how activated prior knowledge guides the updating process that characterises aspects of memory consolidation.

Keywords: memory; novelty; prior knowledge.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Hippocampus / physiology
  • Humans
  • Knowledge*
  • Memory / physiology*
  • Memory Consolidation / physiology*
  • Research*
  • Time