Possible role of cAMP in the differentiation of Trypanosoma cruzi

Mol Biochem Parasitol. 1987 Jan 2;22(1):39-43. doi: 10.1016/0166-6851(87)90067-3.


To assess the possible action of cAMP on the cell differentiation of Trypanosoma cruzi, we determined both cAMP levels and cAMP-binding activities of epimastigotes and trypomastigotes of this parasite. Trypomastigotes showed a 4-fold higher cAMP content and a 2.5-fold increase in the specific activity of a cAMP-binding protein with identical properties to that of epimastigotes. The high levels of cAMP present in trypomastigotes strongly suggest a role of this cyclic nucleotide on the differentiation of T. cruzi.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Centrifugation, Density Gradient
  • Chromatography, DEAE-Cellulose
  • Cyclic AMP / analysis
  • Cyclic AMP / metabolism*
  • Trypanosoma cruzi / cytology
  • Trypanosoma cruzi / metabolism*


  • Cyclic AMP