Specific antigen-Ia activation of transfected human T cells expressing murine Ti alpha beta-human T3 receptor complexes

Nature. 1987 Jan 8-14;325(7000):125-30. doi: 10.1038/325125a0.


The genes encoding the alpha and beta chains of the T-cell receptor (Ti) of an antigen-specific, Ia-restricted murine T-cell hybridoma were introduced into T3-positive or T3-negative human T cells. The resultant transfectants express either mouse-human or mouse-mouse Ti alpha beta molecules functionally associated with the human T3 complex. Only the complete murine Ti alpha beta dimer mediates specific functional corecognition of the appropriate antigen-Ia pair.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Membrane / immunology
  • Cytochrome c Group / immunology
  • Endocytosis
  • Histocompatibility Antigens Class II / genetics
  • Histocompatibility Antigens Class II / immunology*
  • Humans
  • Interleukin-2 / biosynthesis
  • Macromolecular Substances
  • Mice
  • RNA, Messenger / genetics
  • Receptors, Antigen, T-Cell / genetics
  • Receptors, Antigen, T-Cell / immunology*
  • Species Specificity
  • T-Lymphocytes / physiology*
  • Transcription, Genetic
  • Transfection


  • Cytochrome c Group
  • Histocompatibility Antigens Class II
  • Interleukin-2
  • Macromolecular Substances
  • RNA, Messenger
  • Receptors, Antigen, T-Cell