Estimation of Overdiagnosis of Lung Cancer in Low-Dose Computed Tomography Screening: A Secondary Analysis of the Danish Lung Cancer Screening Trial

doi:10.1001/jamainternmed.2018.3056

. 2018 Oct 1;178(10):1420-1422.

doi: 10.1001/jamainternmed.2018.3056.

Estimation of Overdiagnosis of Lung Cancer in Low-Dose Computed Tomography Screening: A Secondary Analysis of the Danish Lung Cancer Screening Trial

Bruno Heleno^{1

2}, Volkert Siersma¹, John Brodersen^{1

3}

Affiliations

¹ The Research Unit for General Practice, Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
² Chronic Diseases Research Centre, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Campo dos Mártires da Pátria, Lisbon, Portugal.
³ Primary Healthcare Research Unit, Region Zealand, Denmark.

PMID: 30276415
PMCID: PMC6233751
DOI: 10.1001/jamainternmed.2018.3056

Estimation of Overdiagnosis of Lung Cancer in Low-Dose Computed Tomography Screening: A Secondary Analysis of the Danish Lung Cancer Screening Trial

Bruno Heleno et al. JAMA Intern Med. 2018.

. 2018 Oct 1;178(10):1420-1422.

doi: 10.1001/jamainternmed.2018.3056.

Authors

Bruno Heleno^{1

2}, Volkert Siersma¹, John Brodersen^{1

3}

Affiliations

¹ The Research Unit for General Practice, Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
² Chronic Diseases Research Centre, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Campo dos Mártires da Pátria, Lisbon, Portugal.
³ Primary Healthcare Research Unit, Region Zealand, Denmark.

PMID: 30276415
PMCID: PMC6233751
DOI: 10.1001/jamainternmed.2018.3056

Abstract

This study analyzes data from the Danish Lung Cancer Screening Trial to determine the amount of overdiagnosis of computed tomography–detected lung cancer.

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Conflict of interest statement

Conflict of Interest Disclosures: None reported.

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Comment in

Accounting for the Harms of Lung Cancer Screening.
Ebell MH, Lin KW. Ebell MH, et al. JAMA Intern Med. 2018 Oct 1;178(10):1422-1423. doi: 10.1001/jamainternmed.2018.3061. JAMA Intern Med. 2018. PMID: 30105383 No abstract available.

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References

1. Pedersen JH, Ashraf H, Dirksen A, et al. . The Danish randomized lung cancer CT screening trial: overall design and results of the prevalence round. J Thorac Oncol. 2009;4(5):608-614. doi:10.1097/JTO.0b013e3181a0d98f - DOI - PubMed
1. Saghir Z, Dirksen A, Ashraf H, et al. . CT screening for lung cancer brings forward early disease: the randomised Danish Lung Cancer Screening Trial: status after five annual screening rounds with low-dose CT. Thorax. 2012;67(4):296-301. doi:10.1136/thoraxjnl-2011-200736 - DOI - PubMed
1. Wille MMW, Dirksen A, Ashraf H, et al. . Results of the randomized Danish Lung Cancer Screening Trial with focus on high-risk profiling. Am J Respir Crit Care Med. 2016;193(5):542-551. doi:10.1164/rccm.201505-1040OC - DOI - PubMed
1. Welch HG, Black WC. Overdiagnosis in cancer. J Natl Cancer Inst. 2010;102(9):605-613. doi:10.1093/jnci/djq099 - DOI - PubMed
1. Patz EF Jr, Pinsky P, Gatsonis C, et al. ; NLST Overdiagnosis Manuscript Writing Team . Overdiagnosis in low-dose computed tomography screening for lung cancer. JAMA Intern Med. 2014;174(2):269-274. doi:10.1001/jamainternmed.2013.12738 - DOI - PMC - PubMed

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[1] Pedersen JH, Ashraf H, Dirksen A, et al. . The Danish randomized lung cancer CT screening trial: overall design and results of the prevalence round. J Thorac Oncol. 2009;4(5):608-614. doi:10.1097/JTO.0b013e3181a0d98f - DOI - PubMed

[2] Pedersen JH, Ashraf H, Dirksen A, et al. . The Danish randomized lung cancer CT screening trial: overall design and results of the prevalence round. J Thorac Oncol. 2009;4(5):608-614. doi:10.1097/JTO.0b013e3181a0d98f - DOI - PubMed

[3] Saghir Z, Dirksen A, Ashraf H, et al. . CT screening for lung cancer brings forward early disease: the randomised Danish Lung Cancer Screening Trial: status after five annual screening rounds with low-dose CT. Thorax. 2012;67(4):296-301. doi:10.1136/thoraxjnl-2011-200736 - DOI - PubMed

[4] Saghir Z, Dirksen A, Ashraf H, et al. . CT screening for lung cancer brings forward early disease: the randomised Danish Lung Cancer Screening Trial: status after five annual screening rounds with low-dose CT. Thorax. 2012;67(4):296-301. doi:10.1136/thoraxjnl-2011-200736 - DOI - PubMed

[5] Wille MMW, Dirksen A, Ashraf H, et al. . Results of the randomized Danish Lung Cancer Screening Trial with focus on high-risk profiling. Am J Respir Crit Care Med. 2016;193(5):542-551. doi:10.1164/rccm.201505-1040OC - DOI - PubMed

[6] Wille MMW, Dirksen A, Ashraf H, et al. . Results of the randomized Danish Lung Cancer Screening Trial with focus on high-risk profiling. Am J Respir Crit Care Med. 2016;193(5):542-551. doi:10.1164/rccm.201505-1040OC - DOI - PubMed

[7] Welch HG, Black WC. Overdiagnosis in cancer. J Natl Cancer Inst. 2010;102(9):605-613. doi:10.1093/jnci/djq099 - DOI - PubMed

[8] Welch HG, Black WC. Overdiagnosis in cancer. J Natl Cancer Inst. 2010;102(9):605-613. doi:10.1093/jnci/djq099 - DOI - PubMed

[9] Patz EF Jr, Pinsky P, Gatsonis C, et al. ; NLST Overdiagnosis Manuscript Writing Team . Overdiagnosis in low-dose computed tomography screening for lung cancer. JAMA Intern Med. 2014;174(2):269-274. doi:10.1001/jamainternmed.2013.12738 - DOI - PMC - PubMed

[10] Patz EF Jr, Pinsky P, Gatsonis C, et al. ; NLST Overdiagnosis Manuscript Writing Team . Overdiagnosis in low-dose computed tomography screening for lung cancer. JAMA Intern Med. 2014;174(2):269-274. doi:10.1001/jamainternmed.2013.12738 - DOI - PMC - PubMed

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Estimation of Overdiagnosis of Lung Cancer in Low-Dose Computed Tomography Screening: A Secondary Analysis of the Danish Lung Cancer Screening Trial

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Estimation of Overdiagnosis of Lung Cancer in Low-Dose Computed Tomography Screening: A Secondary Analysis of the Danish Lung Cancer Screening Trial

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