Zoledronic acid : Treatment option for Gorham-Stout disease

Orthopade. 2018 Dec;47(12):1032-1035. doi: 10.1007/s00132-018-3655-z.

Abstract

Gorham-Stout disease is a rare bone resorption disease, the etiology and prognosis of which is uncertain but it is thought to be benign. It can involve one or more bones and can cause pain, swelling, deformity and fractures in affected bones. Diagnosis is made with a combination of clinical, radiological and histopathological examinations once other causes of osteolysis have been excluded. Due to its rarity, there is no standard therapeutic approach.

Keywords: Bone; Case report; Fractures; Osteolysis; Pain.

Publication types

  • Case Reports

MeSH terms

  • Biopsy
  • Bone Resorption / drug therapy*
  • Female
  • Humans
  • Middle Aged
  • Osteolysis, Essential / drug therapy*
  • Osteolysis, Essential / pathology
  • Treatment Outcome
  • Vitamin D / administration & dosage*
  • Zoledronic Acid / administration & dosage
  • Zoledronic Acid / therapeutic use*

Substances

  • Vitamin D
  • Zoledronic Acid