CaP Coating and Low-Level Laser Therapy to Stimulate Early Bone Formation and Improve Fixation of Rough Threaded Implants

Implant Dent. 2018 Dec;27(6):660-666. doi: 10.1097/ID.0000000000000824.


Purpose: This study aimed to compare in vivo osteogenesis on rough threaded dental implants with and without calcium phosphate (CaP) coating deposition, alone or in association with low-level laser therapy (LLLT) by gallium aluminum arsenide.

Material and methods: Four groups were studied: G1: implant; G2: implant + CaP coating; G3: implant + LLLT; and G4: implant + CaP coating + LLLT. LLLT was applied for 7 days at the surgical site before and after placing the implant. Topographic characterization was performed before surgery using scanning electron microscopy and energy dispersion spectrophotometry. Bone-implant contact (BIC) was measured after 1, 2, and 6 weeks and reverse torque after 6 weeks. In short periods, G2, G3, and G4 showed significantly greater BIC than G1 (P < 0.05), but no difference in BIC was observed at 6 weeks. However, the values for the removal torque test at 6 weeks were higher in G2 and G4 (P < 0.05).

Conclusion: Both CaP coating alone and using LLLT induce cellular stimulation and improve BIC in short-term healing, resulting in higher implant fixation, and should be considered in clinical practice due to their low cost and high effectiveness.

MeSH terms

  • Animals
  • Calcium Phosphates / therapeutic use*
  • Dental Implantation, Endosseous* / instrumentation
  • Dental Implantation, Endosseous* / methods
  • Dental Implants*
  • Low-Level Light Therapy* / methods
  • Male
  • Osteogenesis* / drug effects
  • Osteogenesis* / radiation effects
  • Rabbits
  • Wound Healing / drug effects
  • Wound Healing / radiation effects


  • Calcium Phosphates
  • Dental Implants
  • calcium phosphate