AMPK Regulates the Epigenome through Phosphorylation of TET2

Cell Metab. 2018 Oct 2;28(4):534-536. doi: 10.1016/j.cmet.2018.09.015.

Abstract

Emerging evidence suggests that changes to cellular metabolism can regulate epigenetic modifications to alter gene expression. Recently in Nature, Wu et al. show that the metabolic regulator AMPK can phosphorylate and thus stabilize the epigenetic modifying enzyme TET2, defining a novel signaling link between metabolism and the epigenome.

Publication types

  • Comment

MeSH terms

  • AMP-Activated Protein Kinases
  • DNA-Binding Proteins
  • Diabetes Mellitus*
  • Glucose
  • Humans
  • Neoplasms*
  • Phosphorylation
  • Proto-Oncogene Proteins

Substances

  • DNA-Binding Proteins
  • Proto-Oncogene Proteins
  • TET2 protein, human
  • AMP-Activated Protein Kinases
  • Glucose