Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2018 Oct 3;20(11):98.
doi: 10.1007/s11906-018-0898-3.

Effect of L-Citrulline Supplementation on Blood Pressure: A Systematic Review and Meta-Analysis of Clinical Trials

Affiliations
Meta-Analysis

Effect of L-Citrulline Supplementation on Blood Pressure: A Systematic Review and Meta-Analysis of Clinical Trials

Mohammad Sadegh Mirenayat et al. Curr Hypertens Rep. .

Abstract

Purpose of review: Several interventional studies assessed the impact of dietary supplements on blood pressure. The aim of the present systematic review and meta-analysis was to determine the efficacy of L-citrulline supplementation on blood pressure.

Recent finding: Pubmed, Scopus, Google Scholar, and ISI Web of Science were comprehensively searched until May 2018 to assess whether L-citrulline reduces blood pressure. Human clinical trials which reported the effect of L-citrulline supplementation on aortic and brachial blood pressure were included. Characteristics of studies and potential sources of heterogeneity were tabulated. A subgroup analysis was performed to attenuate observed inter-study heterogeneity. A total of five interventions were found for meta-analysis. The impact of L-citrulline on brachial systolic (change 0.28 mmHg; 95% CI - 2.87, 2.31 mmHg) and diastolic (change - 1.56 mmHg; 95% CI - 4.32, 1.20 mmHg) blood pressure was not significant. Also, there was no changes in aortic systolic (change 0.22 mmHg; 95% CI - 4.81, 4.38 mmHg) and diastolic (change 0.26 mmHg; 95% CI - 2.27, 2.80 mmHg) blood pressure after L-citrulline supplementation. Participants' body weight status was a source of observed heterogeneity. The present systematic review and meta-analysis suggests that L-citrulline supplementation had no beneficial effect on blood pressure.

Keywords: Blood pressure; L-citrulline; Meta-analysis; Systematic review.

Similar articles

See all similar articles

Cited by 4 articles

References

    1. J Cardiol. 2014 Sep;64(3):231-5 - PubMed
    1. Exp Gerontol. 2015 Mar;63:35-40 - PubMed
    1. J Am Coll Cardiol. 2008 Jun 24;51(25):2432-9 - PubMed
    1. Genet Mol Res. 2011 Sep 27;10(3):2202-12 - PubMed
    1. Control Clin Trials. 1986 Sep;7(3):177-88 - PubMed

Publication types

LinkOut - more resources

Feedback