Structural and functional abnormalities in iron-depleted heart

Heart Fail Rev. 2019 Mar;24(2):269-277. doi: 10.1007/s10741-018-9738-4.

Abstract

Iron deficiency (ID) is a common and ominous comorbidity in heart failure (HF) and predicts worse outcomes, independently of the presence of anaemia. Accumulated data from animal models of systemic ID suggest that ID is associated with several functional and structural abnormalities of the heart. However, the exact role of myocardial iron deficiency irrespective of systemic ID and/or anaemia has been elusive. Recently, several transgenic models of cardiac-specific ID have been developed to investigate the influence of ID on cardiac tissue. In this review, we discuss structural and functional cardiac consequences of ID in these models and summarize data from clinical studies. Moreover, the beneficial effects of intravenous iron supplementation are specified.

Keywords: Heart failure; Iron deficiency; Iron supplementation; Myocardial iron deficiency.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Administration, Intravenous
  • Anemia, Iron-Deficiency / complications*
  • Animals
  • Cardiomegaly / metabolism
  • Cardiomegaly / pathology
  • Comorbidity
  • Female
  • Heart / drug effects
  • Heart / physiopathology*
  • Heart Failure / drug therapy
  • Heart Failure / metabolism
  • Heart Failure / mortality
  • Heart Failure / physiopathology*
  • Hepcidins / metabolism
  • Homeostasis / physiology
  • Humans
  • Iron / administration & dosage
  • Iron / blood*
  • Iron / therapeutic use
  • Iron Deficiencies*
  • Iron Metabolism Disorders / complications
  • Male
  • Mice
  • Mice, Transgenic / metabolism
  • Models, Animal
  • Myocardium / metabolism
  • Myocytes, Cardiac / metabolism
  • Nitric Oxide Synthase Type II / metabolism
  • Nitric Oxide Synthase Type III / metabolism
  • Receptors, Transferrin / metabolism

Substances

  • Hepcidins
  • Receptors, Transferrin
  • Tfrc protein, mouse
  • Iron
  • Nitric Oxide Synthase Type II
  • Nitric Oxide Synthase Type III
  • Nos2 protein, mouse
  • Nos3 protein, mouse