Inhibitory Potential against Digestive Enzymes Linked to Obesity and Type 2 Diabetes and Content of Bioactive Compounds in 20 Cultivars of the Peach Fruit Grown in Poland

Plant Foods Hum Nutr. 2018 Dec;73(4):314-320. doi: 10.1007/s11130-018-0688-8.


The presented study provides important insights on the health properties of Prunus persica fruit related to their polyphenol and carotenoid profiles, antioxidant capacity and in vitro potential to inhibit enzymes relevant to type 2 diabetes (α-amylase, α-glucosidase) and obesity (pancreatic lipase) management. Such results have not been published so far. The study showed substantial differences in the chemical composition of peach fruit depending on the cultivar. At the same time, it demonstrated some common features of selected cultivars - the varieties with light flesh ('Spring Time'; 'Madison') were characterized by a high content of phenolic acids and flavonols, thus exhibiting high activity against α-amylase, while the yellow varieties with high content of carotenoids ('Harrow Diamond'; 'Harrow Beauty') showed high inhibitory activity toward porcine pancreatic lipase. Finally, it has been shown that peach fruit is an interesting raw material with a varied chemical composition and nutritional value, especially with high inhibitory potential against digestive enzymes linked to obesity and type 2 diabetes, strongly determined by the cultivar.

Keywords: Antidiabetic activity; Antioxidant capacity; Bioactive compounds; Peach fruit.

MeSH terms

  • Antioxidants / analysis
  • Antioxidants / pharmacology
  • Carotenoids / analysis
  • Diabetes Mellitus, Type 2 / enzymology*
  • Enzyme Inhibitors / pharmacology*
  • Fruit / chemistry
  • Glycoside Hydrolase Inhibitors / pharmacology
  • Humans
  • Obesity / enzymology*
  • Phenols / analysis*
  • Poland
  • Prunus persica / chemistry*


  • Antioxidants
  • Enzyme Inhibitors
  • Glycoside Hydrolase Inhibitors
  • Phenols
  • Carotenoids