Clostridioides difficile Infection

Ann Intern Med. 2018 Oct 2;169(7):ITC49-ITC64. doi: 10.7326/AITC201810020.


Clostridioides difficile (formerly Clostridium difficile) infection is the most frequently identified health care-associated infection in the United States. C difficile has also emerged as a cause of community-associated diarrhea, resulting in increased incidence of community-associated infection. Clinical illness ranges in severity from mild diarrhea to fulminant colitis and death. Appropriate management of infection requires understanding of the various diagnostic assays and therapeutic options as well as relevant measures to infection prevention. This article provides updated recommendations regarding the prevention, diagnosis, and treatment of incident and recurrent C difficile infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / therapeutic use
  • Clostridioides difficile
  • Clostridium Infections / diagnosis
  • Clostridium Infections / prevention & control*
  • Clostridium Infections / therapy
  • Gastrointestinal Microbiome / drug effects
  • Humans


  • Anti-Bacterial Agents