Abstract
We have isolated cDNA clones encoding the beta subunit of the human LFA-1, Mac-1, and p150,95 family of leukocyte adhesion proteins. The deduced 769-amino-acid sequence defines a cysteine-rich polypeptide with the characteristic features of an integral membrane protein. Peptide sequence data, Northern blot analysis, and Southern blot analysis suggest that a single gene encodes the beta subunit of all three leukocyte adhesion proteins. There is 45% homology between the beta subunit sequence and band III of integrin, a chick fibronectin and laminin receptor. This homology defines a new supergene family of cellular adhesion proteins.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Antigens, Surface / genetics*
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Cloning, Molecular
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DNA / isolation & purification
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Extracellular Matrix / metabolism*
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Humans
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Information Systems
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Integrins
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Lymphocyte Function-Associated Antigen-1
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Macromolecular Substances
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Membrane Proteins / genetics
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RNA, Messenger / metabolism
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Receptors, Cell Surface / genetics*
Substances
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Antigens, Surface
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Integrins
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Lymphocyte Function-Associated Antigen-1
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Macromolecular Substances
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Membrane Proteins
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RNA, Messenger
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Receptors, Cell Surface
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DNA