Blood Sugar Regulation for Cardiovascular Health Promotion and Disease Prevention: JACC Health Promotion Series

J Am Coll Cardiol. 2018 Oct 9;72(15):1829-1844. doi: 10.1016/j.jacc.2018.07.081.


The primary objective of this study was to analyze the most up-to-date evidence regarding whether and how blood sugar regulation influences cardiovascular health promotion and disease prevention by carrying out an umbrella review. Three separate, systematic literature searches identified 2,343 papers in total. Overall, 44 studies were included for data extraction and analysis. The included systematic reviews and meta-analyses published between January 1, 2016, and December 31, 2017, were of good to very good quality (median Overview Quality Assessment Questionnaire score = 17). Identified evidence suggests that cardiovascular disease (CVD) prevention services should consider regulation of blood glucose as a key target for intervention. Furthermore, the recommendations for effective intervention and service development/training described here for prevention of CVD should be adopted into evidence-based practice guidelines. Multidisciplinary teams should be formed to deliver multicomponent interventions in community-based settings. There may be substantial opportunities for integrating CVD and diabetes prevention services.

Keywords: blood glucose; diabetes mellitus; diet; exercise; health behavior; umbrella review; weight loss.

Publication types

  • Review

MeSH terms

  • Blood Glucose* / analysis
  • Blood Glucose* / metabolism
  • Cardiovascular Diseases / blood
  • Cardiovascular Diseases / prevention & control
  • Health Promotion / methods*
  • Humans
  • Meta-Analysis as Topic
  • Primary Prevention / methods
  • Systematic Reviews as Topic


  • Blood Glucose