Genomic Alterations Driving Psoriasis Pathogenesis

Gene. 2019 Jan 30;683:61-71. doi: 10.1016/j.gene.2018.09.042. Epub 2018 Oct 1.

Abstract

Psoriasis is an immune mediated inflammatory skin disease with complex etiology involving interplay between environmental and genetic risk factors as disease initiating event. Enhanced understanding on genetic risk factors, differentially expressed genes, deregulated proteins and pathway-targeted therapeutics have established multiple axis of psoriasis pathogenesis. So far, loci in 424 genes are reported to be associated with psoriasis alongside copy number variations and epigenetic alterations. From clinical perspective, presence of specific genetic trigger(s) in individual psoriasis patient could aid in devising a personalized therapeutic strategy. Therefore, the review presents an updates on reported genomic alterations and their subsequent course of cutaneous inflammations that potentially drive to psoriasis.

Keywords: Autoimmunity; Genetic triggers; IL23/Type 17 T cell axis; Keratinocytes; PSORS.

Publication types

  • Review

MeSH terms

  • DNA Copy Number Variations
  • Epigenesis, Genetic
  • Gene Regulatory Networks*
  • Genetic Predisposition to Disease
  • Genetic Variation*
  • Humans
  • Polymorphism, Single Nucleotide
  • Precision Medicine
  • Psoriasis / genetics*