Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals

Int J Mol Sci. 2018 Oct 4;19(10):3031. doi: 10.3390/ijms19103031.


Death associated protein kinase (DAPK) is a calcium/calmodulin-regulated serine/threonine kinase; its main function is to regulate cell death. DAPK family proteins consist of DAPK1, DAPK2, DAPK3, DAPK-related apoptosis-inducing protein kinases (DRAK)-1 and DRAK-2. In this review, we discuss the roles and regulatory mechanisms of DAPK family members and their relevance to diseases. Furthermore, a special focus is given to several reports describing cross-talks between DAPKs and mitogen-activated protein kinases (MAPK) family members in various pathologies. We also discuss small molecule inhibitors of DAPKs and their potential as therapeutic targets against human diseases.

Keywords: DAPK; ERK; JNK; MAPK; p38.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Death-Associated Protein Kinases / antagonists & inhibitors
  • Death-Associated Protein Kinases / metabolism*
  • Humans
  • MAP Kinase Signaling System*
  • Molecular Targeted Therapy / methods
  • Protein Kinase Inhibitors / pharmacology
  • Protein Kinase Inhibitors / therapeutic use


  • Protein Kinase Inhibitors
  • Death-Associated Protein Kinases