Assignment of the prealbumin (PALB) gene (familial amyloidotic polyneuropathy) to human chromosome region 18q11.2-q12.1

Hum Genet. 1987 Feb;75(2):151-4. doi: 10.1007/BF00591077.

Abstract

The assignment of the human prealbumin (PALB) gene to chromosome region 18q11-q12.1 has been achieved using a human genomic probe in the study of human-mouse somatic cell hybrids and by in situ hybridization. Because familial amyloidotic polyneuropathy was reported previously to be due to a mutation in prealbumin, it can be inferred that the gene for this disorder also maps to 18q11.2-q12.1.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amyloidosis / genetics*
  • Animals
  • Chromosome Banding
  • Chromosome Mapping*
  • Chromosomes, Human, Pair 18*
  • DNA / genetics
  • Genetic Markers
  • Humans
  • Hybrid Cells
  • Karyotyping
  • Mice
  • Peripheral Nervous System Diseases / genetics*
  • Prealbumin / genetics*

Substances

  • Genetic Markers
  • Prealbumin
  • DNA