Multiple recycling routes: Canonical vs. non-canonical mitophagy in the heart

Biochim Biophys Acta Mol Basis Dis. 2019 Apr 1;1865(4):797-809. doi: 10.1016/j.bbadis.2018.09.034. Epub 2018 Oct 2.


The heart is composed of cardiomyocytes that require large amounts of energy to sustain contraction. Mitochondria are distinctive organelles of bacterial origin that generate most of the energy for the heart via oxidative phosphorylation. To ensure a healthy population of mitochondria that efficiently produce ATP, myocytes quickly eliminate any unhealthy or unwanted mitochondria via a process known as mitochondrial autophagy, or mitophagy. It is especially important to selectively remove damaged or aged mitochondria since they can become excessive producers of reactive oxygen species and release pro-death proteins. Because this is such a crucial cellular process, cells have several mechanisms in place to deal with potentially harmful mitochondria. Here, we review the various pathways identified to date and how they are regulated. We also discuss the importance of these canonical and non-canonical pathways in the heart and their link to cardiovascular health, disease and aging.

Keywords: Autophagy; BNIP3; Mitophagy; NIX; PARKIN; PINK1; RAB5.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / metabolism
  • Animals
  • Exercise
  • Heart Diseases / metabolism
  • Humans
  • Mitochondria, Heart / metabolism*
  • Mitophagy*
  • Oxidative Stress