Hailey-Hailey disease successfully treated with vitamin D oral supplementation

Dermatol Ther. 2019 Jan;32(1):e12767. doi: 10.1111/dth.12767. Epub 2018 Oct 25.

Abstract

Hailey-Hailey disease (HHD) also known as familial benign chronic pemphigus is a rare autosomal dominant genodermatosis. HHD treatment is often not satisfactory and hence, various modalities of treatment have been tried. We describe the case of a 37-year-old woman with a 2 years history of macerated erythematous plaques along with erosions, fissures, and crusts located on axillae and submammary areas, successfully treated with only oral supplementation of vitamin D (800 I.U./die) for 3 months. We reported this case to suggest that oral vitamin D may be enumerated in the various treatments proposed for HHD so far due to its rapid efficacy on skin lesions and symptoms.

Keywords: 1α,24-dihydroxyvitamin D3; Hailey-Hailey disease; familial benign chronic pemphigus; treatment; vitamin D.

Publication types

  • Case Reports

MeSH terms

  • Administration, Cutaneous
  • Administration, Oral
  • Adult
  • Biopsy
  • Dietary Supplements*
  • Dihydroxycholecalciferols / administration & dosage
  • Female
  • Humans
  • Ointments / administration & dosage
  • Pemphigus, Benign Familial / diagnosis
  • Pemphigus, Benign Familial / drug therapy*
  • Pemphigus, Benign Familial / immunology
  • Remission Induction
  • Skin / drug effects*
  • Skin / immunology
  • Skin / pathology
  • Time Factors
  • Treatment Outcome
  • Vitamin D / administration & dosage*
  • Vitamin D Deficiency / blood
  • Vitamin D Deficiency / diagnosis
  • Vitamin D Deficiency / drug therapy*

Substances

  • Dihydroxycholecalciferols
  • Ointments
  • Vitamin D
  • 1 alpha,24-dihydroxyvitamin D3