Senescent Cells Drive Frailty through Systemic Signals

Johannes Lehmann; Marjolein P Baar; Peter L J de Keizer

doi:10.1016/j.molmed.2018.09.003

Senescent Cells Drive Frailty through Systemic Signals

Trends Mol Med. 2018 Nov;24(11):917-918. doi: 10.1016/j.molmed.2018.09.003. Epub 2018 Oct 3.

Authors

Johannes Lehmann¹, Marjolein P Baar¹, Peter L J de Keizer²

Affiliations

¹ Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, 3584CG Utrecht, The Netherlands.
² Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, 3584CG Utrecht, The Netherlands. Electronic address: p.l.j.dekeizer@umcutrecht.nl.

PMID: 30292430
DOI: 10.1016/j.molmed.2018.09.003

Abstract

Senescent cells drive ageing and the associated loss in health and lifespan. Whether this is mediated by systemic signalling remained unclear. Recently, Xu et al. [1] (Nat. Med. 2018;24:1246-1256) answered this question by injecting senescent cells into young mice and observing a long-lasting increase in frailty and mortality.

Keywords: SASP; ageing; cellular senescence; frailty; paracrine; systemic.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Cellular Senescence
Frailty*
Longevity*
Mice
Signal Transduction