Diversity of Quaternary Structures Regulates Nuclear Receptor Activities

Trends Biochem Sci. 2019 Jan;44(1):2-6. doi: 10.1016/j.tibs.2018.09.005. Epub 2018 Oct 4.


Nuclear receptors (NRs) form homo- and/or heterodimers as central scaffolds of multiprotein complexes, which activate or repress gene transcription to regulate development, homeostasis, and metabolism. Recent studies on NR quaternary structure reveal novel mechanisms of receptor dimerization, the existence of tetrameric chromatin-bound NRs, and previously unanticipated protein-protein/protein-DNA interactions.

Keywords: Nuclear receptors; monomer-oligomer transition; protein–protein interaction surfaces; quaternary structure; structure–function.

MeSH terms

  • Binding Sites
  • DNA / chemistry
  • DNA / metabolism
  • Humans
  • Models, Molecular
  • Protein Binding
  • Protein Structure, Quaternary
  • Receptors, Cytoplasmic and Nuclear / chemistry*
  • Receptors, Cytoplasmic and Nuclear / genetics
  • Receptors, Cytoplasmic and Nuclear / metabolism*


  • Receptors, Cytoplasmic and Nuclear
  • DNA