Treatment of chronic and extreme ocular hypotension following glaucoma surgery with intraocular platelet-rich plasma: A case report

Eur J Ophthalmol. 2019 Jul;29(4):NP9-NP12. doi: 10.1177/1120672118803515. Epub 2018 Oct 7.


Purpose: To report a new approach for the treatment of severe ocular hypotony secondary to glaucoma filtering surgery with mitomycin C by injecting autologous eye platelet-rich plasma (E-PRP) in the anterior chamber to block excessive diffuse filtration through an abnormally thinned sclera.

Methods: A 49-year-old patient with the Axenfeld-Rieger syndrome and severe chronic hypotony and corneal edema following filtering glaucoma surgery with mitomycin C received an isolated injection of 0.3 mL of autologous platelet-rich plasma in the anterior chamber.

Results: Intraocular pressure measured by Goldman's applanation tonometry 6 h after the procedure improved to 18 mmHg. Intraocular pressure remained stable along the full follow-up period of 6 month. No filtration or hypotony or any other complications were observed.

Conclusion: Intracameral platelet-rich plasma (E-PRP) injection was an effective, rapidly effective, and safe procedure for treatment of severe chronic ocular hypotony following glaucoma filtrating surgery.

Keywords: Descemet membrane endothelial keratoplasty; Hypotony; filtration; glaucoma surgery; platelet-rich plasma.

Publication types

  • Case Reports

MeSH terms

  • Alkylating Agents / administration & dosage
  • Anterior Chamber / drug effects
  • Chronic Disease
  • Filtering Surgery / adverse effects*
  • Glaucoma / surgery*
  • Humans
  • Intraocular Pressure / physiology
  • Male
  • Middle Aged
  • Mitomycin / administration & dosage
  • Ocular Hypotension / etiology
  • Ocular Hypotension / physiopathology
  • Ocular Hypotension / therapy*
  • Platelet-Rich Plasma / physiology*
  • Postoperative Complications / surgery
  • Sclera / surgery
  • Tonometry, Ocular


  • Alkylating Agents
  • Mitomycin