Chronic Inflammation in Rheumatoid Arthritis and Mediators of Skeletal Muscle Pathology and Physical Impairment: A Review

Abstract

This review focuses on the effects of chronic systemic inflammation on skeletal muscle and its downstream effect on physical function in individuals with rheumatoid arthritis (RA). The importance of skeletal muscle in the regulation of whole-body glucose and lipid metabolism, and the benefits and barriers to physical activity and exercise training are highlighted. Finally, we identify knowledge gaps that may be important for the development of both pharmacologic and non-pharmacologic interventions (e.g. proper exercise regimens) to protect individuals with RA from physical impairment.