Study of the chemical nature of Frp/3 cell recognition units for hepatitis A virus

Med Microbiol Immunol. 1987;176(1):21-6. doi: 10.1007/BF00189405.


Research has been carried out in order to clarify the chemical nature of cell receptors interacting with a fast growing strain of hepatitis A virus (HAV) producing a cytopathic effect on Frp/3 cells. Cell surface susceptibility to HAV attachment has been studied after treatment with enzymes acting on different chemical groupings. Results obtained showed a lowering of cell susceptibility to HAV infection following the action of phospholipase A2, phospholipase C, trypsin and beta-galactosidase. These data suggested that phospholipids, proteins and galactose participate to the cellular receptorial area for HAV.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line
  • Cytopathogenic Effect, Viral
  • Fluorescent Antibody Technique
  • Galactose / metabolism
  • Glycoside Hydrolases / metabolism
  • Hepatovirus / metabolism*
  • Humans
  • Phospholipases / metabolism
  • Phospholipids / metabolism
  • Proteins / metabolism
  • Receptors, Virus / metabolism*


  • Phospholipids
  • Proteins
  • Receptors, Virus
  • Phospholipases
  • Glycoside Hydrolases
  • Galactose