Cholestenoic acid is a prognostic biomarker in acute respiratory distress syndrome

J Allergy Clin Immunol. 2019 Jan;143(1):440-442.e8. doi: 10.1016/j.jaci.2018.09.017. Epub 2018 Oct 5.

Abstract

Lower plasma levels of the oxysterol cholestenoic acid associate with increased mortality and organ failure in septic patients with acute respiratory distress syndrome (ARDS). Cholestenoic acid warrants further validation as a novel ARDS biomarker.

Publication types

  • Letter
  • Research Support, N.I.H., Intramural

MeSH terms

  • Biomarkers / blood
  • Cholestenes / blood*
  • Cholestenes / immunology
  • Disease-Free Survival
  • Female
  • Humans
  • Male
  • Respiratory Distress Syndrome, Adult / blood*
  • Respiratory Distress Syndrome, Adult / immunology
  • Respiratory Distress Syndrome, Adult / mortality*
  • Survival Rate

Substances

  • Biomarkers
  • Cholestenes
  • cholestenoic acid