Phosphorylation of the AMPAR-TARP Complex in Synaptic Plasticity

Proteomes. 2018 Oct 8;6(4):40. doi: 10.3390/proteomes6040040.


Synaptic plasticity has been considered a key mechanism underlying many brain functions including learning, memory, and drug addiction. An increase or decrease in synaptic activity of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) complex mediates the phenomena as shown in the cellular models of synaptic plasticity, long-term potentiation (LTP), and depression (LTD). In particular, protein phosphorylation shares the spotlight in expressing the synaptic plasticity. This review summarizes the studies on phosphorylation of the AMPAR pore-forming subunits and auxiliary proteins including transmembrane AMPA receptor regulatory proteins (TARPs) and discusses its role in synaptic plasticity.

Keywords: AMPA receptor complex; phosphorylation; synaptic plasticity; transmembrane AMPA receptor regulatory protein.

Publication types

  • Review