Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents

Sci Rep. 2018 Oct 8;8(1):14911. doi: 10.1038/s41598-018-33362-6.


Water soluble spin-crossover (SCO) iron(II) nanoparticles (NPs) were synthesized by the polyethylene glycol (PEG) coating of [Fe(Htrz)3-3×(NH2trz)](BF4)2 (x = 0, 0.1, 0.5 and 1). The NPs with x = 0.1 show gradual SCO behavior over 280-330 K in water. The relaxation times, T1 and T2, were determined and the thermally-responsive T2 values making these NPs a candidate for use as a MRI contrast agent.

Publication types

  • Research Support, Non-U.S. Gov't