Erectile dysfunction treated with intracavernous stem cells: A promising new therapy?

Rev Int Androl. Jul-Sep 2018;16(3):119-127. doi: 10.1016/j.androl.2017.10.003. Epub 2018 Mar 7.

Abstract

In the past decades, great interest has been shown in the development of new therapies for erectile dysfunction. Stem cell therapy has generated promising results in numerous preclinical trials in animal models, which is why has led to the development of the first clinical trials in humans. The main cause involved in the pathophysiology of erectile dysfunction is vascular damage related to endothelial and neuronal injury. The interest in stem cell therapy is justified by their capability to differentiate into specific damaged tissues, including endothelium and nervous tissue, and induction of the host own cell proliferation. Despite the great effort of the many studies carried out to date, knowledge about biological effects, therapeutic efficacy and safety of stem cells therapy for erectile dysfunction is still very limited.

Keywords: Células madre; Disfunción eréctil; Erectile dysfunction; Intracavernoso; Intracavernousal; Stem cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Proliferation / physiology
  • Disease Models, Animal
  • Endothelium, Vascular / pathology*
  • Erectile Dysfunction / physiopathology
  • Erectile Dysfunction / therapy*
  • Humans
  • Male
  • Stem Cell Transplantation / methods*