Comment
doi: 10.1016/j.ccell.2018.09.005.
Complement C5a-Mediated TAM-ing of Antitumor Immunity Drives Squamous Carcinogenesis
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- PMID: 30300576
- DOI: 10.1016/j.ccell.2018.09.005
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Complement C5a-Mediated TAM-ing of Antitumor Immunity Drives Squamous Carcinogenesis
Cancer Cell.
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Free article
Abstract
In this issue of Cancer Cell, Medler et al. demonstrate that fibrinolytic enzyme-mediated generation of complement C5a reprograms tumor-infiltrating C5aR1+ macrophages into an immunosuppressive phenotype that dampens CD8+ T cell responses during squamous carcinogenesis. C5aR1 blockade combined with chemotherapy offers a promising immunomodulatory strategy for treating squamous cell carcinoma.
Copyright © 2018 Elsevier Inc. All rights reserved.
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