Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Oct 8;34(4):531-533.
doi: 10.1016/j.ccell.2018.09.005.

Complement C5a-Mediated TAM-ing of Antitumor Immunity Drives Squamous Carcinogenesis

Affiliations
Free article
Comment

Complement C5a-Mediated TAM-ing of Antitumor Immunity Drives Squamous Carcinogenesis

Dimitrios C Mastellos et al. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Medler et al. demonstrate that fibrinolytic enzyme-mediated generation of complement C5a reprograms tumor-infiltrating C5aR1+ macrophages into an immunosuppressive phenotype that dampens CD8+ T cell responses during squamous carcinogenesis. C5aR1 blockade combined with chemotherapy offers a promising immunomodulatory strategy for treating squamous cell carcinoma.

Comment on

Similar articles

See all similar articles

Cited by 1 article

  • Complementing the Cancer-Immunity Cycle.
    Pio R, Ajona D, Ortiz-Espinosa S, Mantovani A, Lambris JD. Pio R, et al. Front Immunol. 2019 Apr 12;10:774. doi: 10.3389/fimmu.2019.00774. eCollection 2019. Front Immunol. 2019. PMID: 31031765 Free PMC article. Review.

LinkOut - more resources

Feedback