Nervous System Development: Flies and Worms Converging on Neuron Identity Control

Paschalis Kratsios; Oliver Hobert

doi:10.1016/j.cub.2018.08.032

Nervous System Development: Flies and Worms Converging on Neuron Identity Control

Curr Biol. 2018 Oct 8;28(19):R1154-R1157. doi: 10.1016/j.cub.2018.08.032.

Authors

Paschalis Kratsios¹, Oliver Hobert²

Affiliations

¹ Department of Neurobiology, University of Chicago, Chicago, IL 60637, USA. Electronic address: pkratsios@uchicago.edu.
² Department of Biology, Howard Hughes Medical Institute, Columbia University, New York, NY 10027, USA. Electronic address: or38@columbia.edu.

PMID: 30300603
DOI: 10.1016/j.cub.2018.08.032

Abstract

Distinct neuronal cell types display phenotypic similarities such as their neurotransmitter identity. Studies in worms and flies have revealed that this phenotypic convergence can be brought about by distinct transcription factors regulating the same effector genes in different neuron types.

Publication types

Review

MeSH terms

Animals
Caenorhabditis elegans / genetics
Cell Differentiation
Diptera / genetics
Gene Expression Regulation, Developmental / genetics
Nervous System / metabolism*
Nervous System Physiological Phenomena / genetics*
Neurogenesis / genetics*
Neurogenesis / physiology
Neurons / physiology
Neurotransmitter Agents
Phenotype
Transcription Factors / metabolism
Transcriptome / genetics

Substances

Neurotransmitter Agents
Transcription Factors