Nervous System Development: Flies and Worms Converging on Neuron Identity Control

Curr Biol. 2018 Oct 8;28(19):R1154-R1157. doi: 10.1016/j.cub.2018.08.032.

Abstract

Distinct neuronal cell types display phenotypic similarities such as their neurotransmitter identity. Studies in worms and flies have revealed that this phenotypic convergence can be brought about by distinct transcription factors regulating the same effector genes in different neuron types.

Publication types

  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / genetics
  • Cell Differentiation
  • Diptera / genetics
  • Gene Expression Regulation, Developmental / genetics
  • Nervous System / metabolism*
  • Nervous System Physiological Phenomena / genetics*
  • Neurogenesis / genetics*
  • Neurogenesis / physiology
  • Neurons / physiology
  • Neurotransmitter Agents
  • Phenotype
  • Transcription Factors / metabolism
  • Transcriptome / genetics

Substances

  • Neurotransmitter Agents
  • Transcription Factors