Sleep Timing, Stability, and BP in the Sueño Ancillary Study of the Hispanic Community Health Study/Study of Latinos

Chest. 2019 Jan;155(1):60-68. doi: 10.1016/j.chest.2018.09.018. Epub 2018 Oct 6.


Background: Timing and stability of the sleep-wake cycle are potential modifiable risk factors for cardiometabolic disease. The aim of this study was to evaluate the relationship between objective measures of sleep-wake timing and stability with cardiometabolic disease risk.

Methods: In this multicenter, cross-sectional, population-based study, actigraphy data were obtained from the 2,156 adults, aged 18 to 64 years, recruited from the Sueño ancillary study of the Hispanic Community Health Study/Study of Latinos (2010-2013). These data were correlated with measures of cardiometabolic disease risk, including systolic and diastolic BPs, homeostatic assessment of insulin resistance, glycosylated hemoglobin, BMI, and hypertension and diabetes status.

Results: Each 10% decrease in interdaily stability was associated with a 3.0% absolute increase in the prevalence of hypertension (95% CI, 0.6-5.3; P < .05), an increase in systolic BP by 0.78 mm Hg (95% CI, 0.12-1.45; P < .05) and an increase in diastolic BP by 0.80 mm Hg (95% CI, 0.28-1.32; P < .05). In addition, delaying the midpoint of sleep by 1 h was associated with an increase in systolic BP by 0.73 mm Hg (95% CI, 0.30-1.16; P < .01) and diastolic BP by 0.53 mm Hg (95% CI, 0.17-0.90; P < .01). These associations were not significant after adjusting for shift work status. No association was found between interdaily stability or sleep timing and diabetes, BMI, or insulin resistance.

Conclusions: These results suggest that beyond sleep duration, the timing and regularity of sleep-wake schedules are related to hypertension prevalence and BP.

Keywords: cardiovascular diseases; circadian rhythm; hypertension; sleep.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Actigraphy
  • Adolescent
  • Adult
  • Blood Pressure / physiology*
  • Circadian Rhythm / physiology*
  • Cross-Sectional Studies
  • Female
  • Follow-Up Studies
  • Hispanic or Latino*
  • Humans
  • Incidence
  • Information Systems
  • Male
  • Middle Aged
  • Prevalence
  • Public Health*
  • Retrospective Studies
  • Self Report
  • Sleep / physiology*
  • Sleep Initiation and Maintenance Disorders / ethnology
  • Sleep Initiation and Maintenance Disorders / physiopathology*
  • Time Factors
  • United States / epidemiology
  • Young Adult