Trimodal synergistic antitumor drug delivery system based on graphene oxide

Xuwu Zhang; Liyao Luo; Lei Li; Yuchu He; Weiwei Cao; Huan Liu; Kang Niu; Dawei Gao

doi:10.1016/j.nano.2018.09.008

Trimodal synergistic antitumor drug delivery system based on graphene oxide

Nanomedicine. 2019 Jan;15(1):142-152. doi: 10.1016/j.nano.2018.09.008. Epub 2018 Oct 6.

Authors

Xuwu Zhang¹, Liyao Luo², Lei Li², Yuchu He², Weiwei Cao³, Huan Liu², Kang Niu², Dawei Gao⁴

Affiliations

¹ Applying Chemistry Key Lab of Hebei Province, Department of Bioengineer, Yanshan University, Qinhuangdao, China; State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao, China.
² Applying Chemistry Key Lab of Hebei Province, Department of Bioengineer, Yanshan University, Qinhuangdao, China.
³ Applying Chemistry Key Lab of Hebei Province, Department of Bioengineer, Yanshan University, Qinhuangdao, China; Hebei Province Asparagus Industry Technology Research Institute, Qinhuangdao, China.
⁴ Applying Chemistry Key Lab of Hebei Province, Department of Bioengineer, Yanshan University, Qinhuangdao, China; State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao, China; Hebei Province Asparagus Industry Technology Research Institute, Qinhuangdao, China. Electronic address: dwgao@ysu.edu.cn.

PMID: 30300749
DOI: 10.1016/j.nano.2018.09.008

Abstract

A multifunctional antitumor drug delivery system was synthesized based on graphene oxide (GO) for near-infrared (NIR) light controlling chemotherapeutic/photothermal (PTT) /photodynamic (PDT) trimodal synergistic therapy. The system named ICG-Wed-GO was formed by co-loading wedelolactone (Wed) and indocyanine green (ICG) on the surface of GO through π-π stacking interaction. Under NIR laser irradiation, ICG-Wed-GO could effectively absorb and transform optical energy to heat, generate reactive oxygen species (ROS) to ablating and damage tumor cells. The temperature of ICG-Wed-GO solution reached up to 79.4 °C in 10 min with NIR irradiation. In in vitro and in vivo study, ICG-Wed-GO showed excellent antitumor effect. After 14-day treatment of ICG-Wed-GO with NIR laser irradiation, the tumor disappeared completely on tumor-bearing mice. The low biotoxicity of ICG-Wed-GO was also proved. The system achieved the synergistic trimodal chemotherapeutic/photothermal/photodynamic treatment and demonstrated excellent antitumor effect, which is expected to have a greater potential for cancer therapy.

Keywords: Drug delivery system; Graphene oxide; Indocyanine green; Synergistic antitumor; Wedelolactone.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Coloring Agents / administration & dosage
Coloring Agents / chemistry
Coumarins / chemistry*
Drug Delivery Systems*
Female
Graphite / chemistry*
Hyperthermia, Induced*
Indocyanine Green / administration & dosage*
Indocyanine Green / chemistry
Mice
Photochemotherapy*
Reactive Oxygen Species
Tumor Cells, Cultured
Uterine Cervical Neoplasms / pathology
Uterine Cervical Neoplasms / therapy*

Substances

Coloring Agents
Coumarins
Reactive Oxygen Species
graphene oxide
wedelolactone
Graphite
Indocyanine Green