Targeting neuro-immune communication in neurodegeneration: Challenges and opportunities

J Exp Med. 2018 Nov 5;215(11):2702-2704. doi: 10.1084/jem.20181737. Epub 2018 Oct 9.


Immune cells patrol the brain and can support its function, but can we modulate brain-immune communication to fight neurological diseases? Here, we briefly discuss the mechanisms orchestrating the cross-talk between the brain and the immune system and describe how targeting this interaction in a well-controlled manner could be developed as a universal therapeutic approach to treat neurodegeneration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / immunology*
  • Brain / pathology
  • Humans
  • Inflammation / immunology
  • Inflammation / pathology
  • Inflammation / therapy
  • Neurodegenerative Diseases / immunology*
  • Neurodegenerative Diseases / pathology
  • Neurodegenerative Diseases / therapy*