Arid5a makes the IL-17A/F-responsive pathway less arid

Sci Signal. 2018 Oct 9;11(551):eaau8876. doi: 10.1126/scisignal.aau8876.


The cytokine interleukin-17A/F (IL-17A/F) not only protects the skin and mucosae against Candida albicans infection in mice and humans but also promotes autoimmunity and autoinflammation in mice. In this issue of Science Signaling, Amatya et al report that the RNA binding protein Arid5a promotes responses to IL-17A/F through multiple mechanisms.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Autoimmunity
  • Cytokines
  • DNA-Binding Proteins
  • Humans
  • Interleukin-17*
  • Mice
  • RNA-Binding Proteins*
  • Transcription Factors


  • Arid5a protein, mouse
  • Cytokines
  • DNA-Binding Proteins
  • Interleukin-17
  • RNA-Binding Proteins
  • Transcription Factors