Energy Constraint as a Novel Mechanism Linking Exercise and Health

Physiology (Bethesda). 2018 Nov 1;33(6):384-393. doi: 10.1152/physiol.00027.2018.


Humans and other species adapt dynamically to changes in daily physical activity, maintaining total energy expenditure within a narrow range. Chronic exercise thus suppresses other physiological activity, including immunity, reproduction, and stress response. This exercise-induced downregulation improves health at moderate levels of physical activity but can be detrimental at extreme workloads.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Energy Metabolism / physiology*
  • Exercise / physiology*
  • Health
  • Humans
  • Motor Activity / physiology