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. 2019 Jan 8;47(D1):D786-D792.
doi: 10.1093/nar/gky930.

Genenames.org: The HGNC and VGNC Resources in 2019

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Free PMC article

Genenames.org: The HGNC and VGNC Resources in 2019

Bryony Braschi et al. Nucleic Acids Res. .
Free PMC article

Abstract

The HUGO Gene Nomenclature Committee (HGNC) based at EMBL's European Bioinformatics Institute (EMBL-EBI) assigns unique symbols and names to human genes. There are over 40 000 approved gene symbols in our current database of which over 19 000 are for protein-coding genes. The Vertebrate Gene Nomenclature Committee (VGNC) was established in 2016 to assign standardized nomenclature in line with human for vertebrate species that lack their own nomenclature committees. The VGNC initially assigned nomenclature for over 15000 protein-coding genes in chimpanzee. We have extended this process to other vertebrate species, naming over 14000 protein-coding genes in cow and dog and over 13 000 in horse to date. Our HGNC website https://www.genenames.org has undergone a major design update, simplifying the homepage to provide easy access to our search tools and making the site more mobile friendly. Our gene families pages are now known as 'gene groups' and have increased in number to over 1200, with nearly half of all named genes currently assigned to at least one gene group. This article provides an overview of our online data and resources, focusing on our work over the last two years.

Figures

Figure 1.
Figure 1.
The proportion of HGNC gene symbols annotated with each locus type. The main doughnut chart shows the proportions of major locus groups. The purple region represents genes annotated with the non-protein-coding RNA locus group; the smaller chart shows the proportion of RNA genes annotated with each RNA-specific locus type. The ‘misc RNA’ category groups together RNA locus types that represent a small number of genes. A full list of locus types, along with total numbers of approved symbols for each category, can be viewed at our Statistics and Downloads facility (www.genenames.org/stats).
Figure 2.
Figure 2.
Genes with approved nomenclature for VGNC species that have been auto approved or manually curated.
Figure 3.
Figure 3.
Screenshots to show the homepage, an example search results page and a gene symbol report page from the HGNC website (https://www.genenames.org).

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