REM sleep deprivation up-regulates adenosine A1 receptors

Brain Res. 1987 Feb 3;402(2):362-4. doi: 10.1016/0006-8993(87)90046-1.


Adenosine receptor binding was determined in the brains of rats deprived of rapid eye movement (REM) sleep for 48 and 96 h using [3H]L-phenylisopropyladenosine. Adenosine A1 receptors (Bmax) were significantly increased in the cortex and corpus striatum, and this increase was sleep-specific. Endogenous adenosine was assayed in microwave-fixed brain tissue and no significant changes were found in REM-deprived rats.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adenosine / metabolism*
  • Animals
  • Brain / metabolism
  • Male
  • Phenylisopropyladenosine
  • Rats
  • Rats, Inbred Strains
  • Receptors, Cell Surface / physiology*
  • Sleep Deprivation / physiology*
  • Sleep, REM*
  • Tritium


  • Receptors, Cell Surface
  • Tritium
  • Phenylisopropyladenosine
  • Adenosine