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. 2018 Dec;46(12):5228-5236.
doi: 10.1177/0300060518800588. Epub 2018 Oct 10.

Serum levels of IL-6, IL-8, and IL-10 are indicators of prognosis in pancreatic cancer

Lanyun Feng  1   2 , Qi Qi  1   2 , Peng Wang  1   2 , Hao Chen  1   2 , Zhen Chen  1   2 , Zhiqiang Meng  1   2 , Luming Liu  1   2
Affiliations

Serum levels of IL-6, IL-8, and IL-10 are indicators of prognosis in pancreatic cancer

Lanyun Feng et al. J Int Med Res. 2018 Dec.

Abstract

Objective: Early detection and prognosis prediction are critical to improve patient survival in pancreatic cancer. This study aimed to investigate whether interleukins could serve as indicators of prognosis in pancreatic cancer.

Methods: Sixty-eight patients with pancreatic cancer were enrolled in the study during the period between 2012 and 2014. The serum levels of a broad spectrum of interleukins in these patients were determined, including IL-1β, IL-2, IL-6, IL-8, IL-10, IL-13, IL-15, and IL-23.

Results: IL-6, IL-8, and IL-10 showed significant positive correlations with each other. Moreover, high levels of serum IL-6, IL-8, and IL-10 were independently strongly associated with poor survival of patients with pancreatic cancer.

Conclusions: Our results suggest that serum levels of IL-6, IL-8, and IL-10 could be useful markers for prediction of prognosis in patients with pancreatic cancer.

Keywords: IL-10; IL-6; IL-8; Pancreatic cancer; interleukin; prediction marker.

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Figures

Figure 1.
Figure 1.
General characteristics of age and overall survival among all patients.
Figure 2.
Figure 2.
Serum interleukin concentrations in patients with pancreatic cancer. Standard deviation (SD) is shown as error bars.
Figure 3.
Figure 3.
IL-6, IL-8, and IL-10 levels were associated with overall survival (OS) in patients with pancreatic cancer. Kaplan-Meier curves (a) and Hazard ratios (b) for OS for all cases. The median level for each group was selected as the cut-off.
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