Nephroprotective Effect of Essential Oils from Ginger (Zingiber officinale) and Turmeric (Curcuma longa) Rhizomes against Cadmium-induced Nephrotoxicity in Rats

J Oleo Sci. 2018;67(10):1339-1345. doi: 10.5650/jos.ess18115.


Several studies have shown that cadmium (Cd) induces nephrotoxicity and many plant foods phytochemicals have been found useful but their possible mechanism of action still remains unexplored. Hence, this study aimed to investigate the nephroprotective effect of essential oils from Nigeria ginger and turmeric rhizomes in cadmium-treated rats by examining their effect on renal function biomarkers (creatinine, urea and BUN), inflammatory cytokines (IL-6, IL-10 and TNF-Alpha) and renal adenosine deaminase (ADA) activity. The result revealed that essential oils from ginger and turmeric rhizomes exert anti-inflammatory effect by preventing alterations of renal function markers and cytokines (IL-6, IL-10 and TNF-Alpha) levels in Cd-treated rats. In addition, the essential oils inhibited renal ADA activity in Cdtreated rats. In conclusion, inhibition of ADA activity and modulation of inflammatory cytokines could be suggested as the possible mechanism of action by which essential oils from ginger and turmeric rhizomes exert their nephroprotective activities.

Keywords: ADA; cytokines; essential oil; nephrotoxicity.

MeSH terms

  • Adenosine Deaminase / metabolism
  • Adenosine Deaminase Inhibitors
  • Animals
  • Anti-Inflammatory Agents*
  • Biomarkers / blood
  • Biomarkers / metabolism
  • Blood Urea Nitrogen
  • Cadmium / toxicity*
  • Creatine / blood
  • Inflammation Mediators / blood
  • Interleukin-10 / blood
  • Interleukin-6 / blood
  • Kidney / metabolism
  • Male
  • Nephritis / chemically induced*
  • Nephritis / diagnosis
  • Nephritis / prevention & control*
  • Oils, Volatile / administration & dosage*
  • Oils, Volatile / isolation & purification
  • Oils, Volatile / pharmacology*
  • Phytotherapy*
  • Rats
  • Tumor Necrosis Factor-alpha / blood
  • Urea / blood
  • Zingiber officinale / chemistry*


  • Adenosine Deaminase Inhibitors
  • Anti-Inflammatory Agents
  • Biomarkers
  • Inflammation Mediators
  • Interleukin-6
  • Oils, Volatile
  • Tumor Necrosis Factor-alpha
  • Cadmium
  • Interleukin-10
  • Urea
  • Adenosine Deaminase
  • Creatine