Generation of Functional Human Adipose Tissue in Mice from Primed Progenitor Cells

Tissue Eng Part A. 2019 Jun;25(11-12):842-854. doi: 10.1089/ten.TEA.2018.0067. Epub 2019 Jan 4.


This research describes the use of human mesenchymal progenitor cells for generating functional adipose tissue in vivo in a nude mouse model. Further preclinical development of the methods and insights described in this article can lead to therapeutic use of these cells in regenerative and reconstructive medicine.

Keywords: adipocytes; adipogenesis; adipose tissue; extracellular matrix; mice; nude; regenerative medicine; stem cells.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adipocytes / cytology
  • Adipocytes / metabolism*
  • Adipose Tissue / cytology
  • Adipose Tissue / metabolism*
  • Animals
  • Cell Differentiation*
  • Heterografts
  • Humans
  • Male
  • Mesenchymal Stem Cell Transplantation*
  • Mesenchymal Stem Cells / cytology
  • Mesenchymal Stem Cells / metabolism*
  • Mice
  • Mice, Nude