Open Sesame: New Keys to Unlocking the Gate to Norovirus Infection

Cell Host Microbe. 2018 Oct 10;24(4):463-465. doi: 10.1016/j.chom.2018.09.018.


Three recent papers highlight the impact of an entry receptor on murine norovirus pathogenesis. CD300lf was shown to be the first proteinaceous entry receptor for a norovirus, specialized intestinal epithelial cells constitute the reservoir for persistence, and a new link between the receptor and a lipid biosynthetic enzyme was revealed.

MeSH terms

  • Animals
  • Caliciviridae Infections / virology*
  • Epithelial Cells / virology
  • Intestines / virology
  • Mice
  • Norovirus*
  • Sesamum*